September 2, 2014Cardiovascular ResearchOpen Access

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

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Structured PICO

Population

Cardiac myocytes from mice: wild-type (WT), phospholamban-knockout (PLN-KO), and mice expressing slow skeletal troponin I (ssTnI)

Intervention

Beta-adrenoceptor agonist isoproterenol (ISO)

Comparator

Baseline/unstimulated state

Outcome

Changes in Ca bufferingsurrogate

During beta-adrenergic stimulation, SERCA and troponin counterbalance each other to maintain constant calcium buffering in cardiac myocytes.

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Does not support clinical translation; leaves open SERCA-troponin counterbalance as target in human Ca handling.

Briston et al. (2014) studied this question.

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