Population
Rabbit isolated cardiomyocytes
Comparison
Transfection with adenoviruses encoding SERCA1a… vs Transfection with adenoviruses encoding…
Design
Preclinical
Authors
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Excessive SERCA1a expression may impair myocyte shortening despite enhanced Ca2+ uptake; hypothesis-generating for dose optimization in cardiac gene therapy.
Moderate SERCA1a gene transfer improves contractility and Ca2+ cycling, but excessive expression impairs myocyte shortening due to higher SERCA activity and Ca2+ buffering.
Teucher et al. (2004) studied this question.
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