November 2, 1998Circulation Research

Enhanced Myocardial Contractility and Increased Ca 2+ Transport Function in Transgenic Hearts Expressing the Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase

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Population

Transgenic mice specifically overexpressing SERCA1a in the heart, using the cardiac-specific alpha-myosin…

Comparison

Cardiac-specific overexpression of the… vs Non-transgenic controls (implied)

Design

Preclinical

Authors

ELEvgeny LoukianovLomonosov Moscow State University YJYong JiNingbo University IGIngrid L. GruppSabin Vaccine Institute

Discussion

Member takes

Implication

Enhances contractility in transgenic mice; hypothesis-generating for SERCA-targeted therapies in human HF.

Structured PICO

Population

Transgenic (TG) mice specifically overexpressing SERCA1a in the heart, using the cardiac-specific alpha-myosin heavy chain promoter

Intervention

Cardiac-specific overexpression of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ transport pump (SERCA1a)

Comparator

Non-transgenic controls (implied)

Outcome

Cardiac contractility and Ca2+ transport function (including maximal velocity of Ca2+ uptake, cytosolic calcium signal, and rates of contraction/relaxation)surrogate

Cardiac-specific overexpression of the fast-twitch skeletal muscle SERCA1a pump enhances myocardial calcium transport and contractility in transgenic mice, demonstrating that SERCA pump levels are critical determinants of cardiac contractility.

Cite This Study

Loukianov et al. (1998) studied this question.

synapsesocial.com/papers/6a76291bcd662f67b2fbde2d https://doi.org/10.1161/01.res.83.9.889

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Enhanced Myocardial Contractility and Increased Ca 2+ Transport Function in Transgenic Hearts Expressing the Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enhanced Myocardial Contractility and Increased Ca 2+ Transport Function in Transgenic Hearts Expressing the Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ -ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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