Why the study?
Does transgenic overexpression of a high calcium affinity SERCA2a mutant prevent pressure overload cardiac hypertrophy in mice?
Population
Mice subjected to pressure overload by transverse aortic constriction
Comparison
Transgenic overexpression of a high calcium… vs Nontransgenic littermate controls
Design
Preclinical
Authors
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Suggests SERCA2a affinity modulation as hypertrophy target; hypothesis-generating in mice, needs human validation.
Does transgenic overexpression of a high calcium affinity SERCA2a mutant prevent pressure overload cardiac hypertrophy in mice?
Increasing SERCA2a calcium affinity attenuates pressure overload-induced cardiac hypertrophy in vivo, suggesting a novel therapeutic target for heart failure.
Nakayama et al. (2002) studied this question.
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