Why the study?
Does phosphorylation of cardiac troponin I by PKA increase the rate of cardiac muscle relaxation in cardiac skinned muscle preparations?
Does phosphorylation of cardiac troponin I by PKA increase the rate of cardiac muscle relaxation in cardiac skinned muscle preparations?
Phosphorylation of cardiac troponin I by PKA directly increases the rate of cardiac muscle relaxation, providing a mechanistic basis for the heart's response to catecholamines.
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Supports CTnI phosphorylation in lusitropy mechanisms; leaves open translation to intact human myocardium.
Zhang et al. (1995) studied this question.
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