June 1, 1995Circulation Research

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

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Why the study?

Does phosphorylation of cardiac troponin I by PKA increase the rate of cardiac muscle relaxation in cardiac skinned muscle preparations?

Population

Cardiac skinned muscle preparation

Comparison

Phosphorylation by protein kinase A (PKA) vs Unphosphorylated state (baseline)

Design

Preclinical

Authors

RZRen ZhangWayne State University JZJiaju ZhaoInstitute of Earth Environment AMAlan MandvenoUniversity of Miami

Discussion

Member takes

Implication

Supports CTnI phosphorylation in lusitropy mechanisms; leaves open translation to intact human myocardium.

Structured PICO

Does phosphorylation of cardiac troponin I by PKA increase the rate of cardiac muscle relaxation in cardiac skinned muscle preparations?

Population

Cardiac skinned muscle preparation

Intervention

Phosphorylation by protein kinase A (PKA)

Comparator

Unphosphorylated state (baseline)

Outcome

Rate of cardiac muscle relaxation (time of half-relaxation, t1/2) and Ca2+ sensitivity of muscle contraction (pCa50)surrogate

Phosphorylation of cardiac troponin I by PKA directly increases the rate of cardiac muscle relaxation, providing a mechanistic basis for the heart's response to catecholamines.

Cite This Study

Zhang et al. (1995) studied this question.

synapsesocial.com/papers/6a0e9ece25c30b2cc7f99df7 https://doi.org/10.1161/01.res.76.6.1028

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Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider