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October 1, 1991AJP Heart and Circulatory Physiology

Phospholamban mediates the beta-adrenergic-enhanced Ca2+ uptake in mammalian ventricular myocytes

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Population

Intact whole cell clamped guinea pig ventricular myocytes and guinea pig ventricular sarcoplasmic reticular…

Comparison

Monoclonal antibody (2D12) against phospholamban vs Control conditions without antibody

Design

Preclinical

Authors

JSJames S.K. ShamLJL. R. JonesMMMartin Morad

Discussion

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Overview

Antibody effects on Ca2+ handling are hypothesis-generating in animal models; leaves open relevance to human cardiac disease.

Structured PICO

P
Population
Intact whole cell clamped guinea pig ventricular myocytes and guinea pig ventricular sarcoplasmic reticular vesicles
I
Intervention
Monoclonal antibody (2D12) against phospholamban
C
Comparator
Control conditions without antibody
O
Outcome
Intracellular Ca2+ transient, Ca2+ current, and rate of Ca2+ uptake and releasesurrogate

Phosphorylation of phospholamban is crucial for Ca2+ sequestration by the sarcoplasmic reticulum and mediates the catecholamine-enhanced rate of Ca2+ uptake and release in heart muscle.

Cite This Study

Sham et al. (1991) studied this question.

synapsesocial.com/papers/6a0e9ece25c30b2cc7f99dfehttps://doi.org/10.1152/ajpheart.1991.261.4.h1344
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