Key result
Anti-phospholamban antibody stimulated Ca2+ uptake equally in normal (1.93-fold) and failing (1.94-fold) human hearts, showing this mechanism is unaltered in idiopathic dilated cardiomyopathy.
Why the study?
Does anti-phospholamban monoclonal antibody stimulate Ca2+ uptake similarly in sarcoplasmic reticulum from normal and failing human hearts?
Does anti-phospholamban monoclonal antibody stimulate Ca2+ uptake similarly in sarcoplasmic reticulum from normal and failing human hearts?
Effect estimate: 1.93-fold (normal) and 1.94-fold (failing)
Phospholamban-mediated stimulation of Ca2+ uptake is preserved in human idiopathic dilated cardiomyopathy, suggesting the pathogenesis of heart failure in this condition does not involve intrinsic alterations of this mechanism.
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Preserved phospholamban-mediated Ca2+ uptake in failing hearts warrants no practice change; leaves open its therapeutic targeting in idiopathic dilated cardiomyopathy.
Movsesian et al. (1990) studied Idiopathic dilated cardiomyopathy (n=21). Anti-phospholamban monoclonal antibody vs. Absence of antibody was evaluated on Stimulation of Ca2+ uptake at 0.2 µM Ca2+ (1.93-fold (normal) and 1.94-fold (failing)). Anti-phospholamban antibody stimulated Ca2+ uptake equally in normal (1.93-fold) and failing (1.94-fold) human hearts, showing this mechanism is unaltered in idiopathic dilated cardiomyopathy.
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