Key result
Phospholamban is a key regulator of cardiac contractility that modulates sarcoplasmic reticulum calcium sequestration, presenting a potential therapeutic target for the treatment of heart failure.
Design
Review
Authors
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Phospholamban modulation may warrant preclinical pursuit in heart failure; leaves open clinical translation and outcome trials.
This review highlights the critical role of phospholamban in regulating cardiac contractility and its potential as a therapeutic target in heart failure.
Frank et al. (2000) conducted a review in Heart failure. Phospholamban was evaluated. Phospholamban is a key regulator of cardiac contractility that modulates sarcoplasmic reticulum calcium sequestration, presenting a potential therapeutic target for the treatment of heart failure.
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