What question did this study set out to answer?

Investigate the molecular mechanisms and interplay between the transcription factor Runx1 and cyclin-dependent kinase inhibitors, particularly p21, in governing hair follicle stem cell quiescence.

March 4, 2013Proceedings of the National Academy of SciencesOpen Access

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo

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Authors

JLJayhun LeeThe University of Texas MD Anderson Cancer Center CHCharlene S. L. HoiUniversity of Chicago KLKarin LiljaAstraZeneca (Finland)

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Implication

Experimental study reveals Runx1 and p21 synergistically repress p15 to limit hair follicle stem cell quiescence in vivo, highlighting a noncanonical transcriptional role for p21.

Key Points

Investigate the molecular mechanisms and interplay between the transcription factor Runx1 and cyclin-dependent kinase inhibitors, particularly p21, in governing hair follicle stem cell quiescence.
Profiled the expression of cyclin-dependent kinase inhibitors (including p21, p57, and p15) and Runx1 in hair follicle stem cells during tissue homeostasis in vivo.
Assessed functional interactions between Runx1 and p21 across normal tissue homeostasis, cell culture models, and tumors.
Analyzed transcriptional regulation and promoter binding of downstream cell-cycle inhibitors in cultured keratinocytes.
The cyclin-dependent kinase inhibitors p21, p57, and p15 are upregulated at quiescence onset, while Runx1 represses p21, p27, p57, and p15 transcription in vivo.
Runx1 and p21 synergistically restrict the extent of hair follicle stem cell quiescence in vivo, counteracting the canonical role of p21 as a cell-cycle inhibitor.
Runx1 and p21 directly bind the p15 promoter in cultured keratinocytes to synergistically suppress p15 mRNA transcription, establishing p21 as a direct repressor of another cyclin-dependent kinase inhibitor.

Cite This Study

Lee et al. (2013) studied this question.

synapsesocial.com/papers/6a0e9f632eca052da647a0ba https://doi.org/10.1073/pnas.1213015110

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Implication

Experimental study reveals Runx1 and p21 synergistically repress p15 to limit hair follicle stem cell quiescence in vivo, highlighting a noncanonical transcriptional role for p21.

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo

Discussion

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Implication

Key Points

Cite This Study

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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