Why the study?
Do HERG mutations prolong action potential duration and generate early afterdepolarizations in a virtual cardiac ventricular cell model?
Population
Virtual transgenic cell model of cardiac ventricular cells incorporating Markovian models of wild-type and…
Comparison
HERG mutations (mutant I(Kr) channels) vs Wild-type (WT) I(Kr) channels
Design
Preclinical
Authors
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Hypothesis-generating in virtual LQT2 models; leaves open human translation and clinical adoption.
Do HERG mutations prolong action potential duration and generate early afterdepolarizations in a virtual cardiac ventricular cell model?
Computational modeling demonstrates that HERG mutations in LQT2 prolong action potential duration and generate early afterdepolarizations by causing a net loss of repolarizing current.
Colleen E. Clancy (2001) studied this question.