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May 21, 2026Scientific ReportsOpen Access

Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes

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Authors

KSKartiki SrivastavaInstitute of Medical SciencesSKSalman KhanKing Saud UniversityRPRajniti PrasadSir Sunderlal Hospital

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Implication

Randomized trial examines pyrazinamide resistance in multidrug-resistant tuberculosis strains, suggesting targeted therapy improvements.

Key Points

  • This study aims to investigate the relationship between pyrazinamide resistance and gene mutations in Mycobacterium tuberculosis.
  • Analyzed 780 MTB-positive strains for drug resistance using a line probe assay.
  • Conducted phenotypic drug susceptibility testing for pyrazinamide using MGIT 960 liquid culture.
  • Sequenced the pncA gene to determine mutation patterns in resistant strains.
  • Out of 780 strains, 195 were resistant to first-line drugs, with 107 resistant and 88 susceptible to pyrazinamide.
  • The most common mutations were S531L in rpoB, S315T in katG, and C-15T in inhA.
  • There were 23 pncA gene mutations found in 24 pyrazinamide-resistant strains, indicating a strong link between mutation presence and drug resistance.

Cite This Study

Srivastava et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea02cbe05d6e3efb5f1achttps://doi.org/10.1038/s41598-026-53296-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The influence of pyrazinamide resistant associated gene mutations on multidrug-resistant mycobacterium tuberculosis in China2024
  2. 2Enhancing diagnostic efficiency of pyrazinamide resistance in Mycobacterium tuberculosis via modified MGIT assay and genotypic correlation2025 · 3 citations
  3. 3Genetic analysis of pyrazinamide resistance: mutations in the pncA gene among clinical isolates of multi-drug resistant Mycobacterium Tuberculosis2024
  4. 4Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India2024 · 1 citations
  5. 5Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China2026