What question did this study set out to answer?

To update a systematic review evaluating the effects of interventions designed to enhance patient adherence to prescribed medications and improve clinical outcomes across medical disorders.

October 7, 2005Cochrane library

Interventions for enhancing medication adherence

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To update a systematic review evaluating the effects of interventions designed to enhance patient adherence to prescribed medications and improve clinical outcomes across medical disorders.
Searched seven electronic databases up to September 2004 without language restrictions for unconfounded randomized controlled trials (RCTs) evaluating medication adherence interventions.
Included studies with at least 80% follow-up per group that measured both medication adherence and clinical treatment outcomes, requiring at least six months of follow-up for long-term treatments with initial positive findings.
For short-term treatments, 4 of 9 interventions across 8 RCTs significantly improved both adherence and at least one clinical outcome, while 1 intervention improved adherence without clinical benefit.
For long-term treatments, 26 of 58 interventions across 49 RCTs improved adherence, but only 18 improved at least one clinical outcome, with effective strategies relying on complex combinations of reminders, counseling, and monitoring that yielded modest effect sizes.
Across six RCTs assessing patient education regarding adverse effects, informing patients about medication side effects did not adversely impact adherence.

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Implication

Systematic review demonstrates that complex interventions modestly improve adherence and clinical outcomes in chronic illness, highlighting the need for better long-term strategies.

Cite This Study

Haynes et al. (2005) studied this question.

synapsesocial.com/papers/6a0ea0a1a14f152feaf9a027 https://doi.org/10.1002/14651858.cd000011.pub2

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Implication

Systematic review demonstrates that complex interventions modestly improve adherence and clinical outcomes in chronic illness, highlighting the need for better long-term strategies.

Interventions for enhancing medication adherence

Key Points

Discussion

Implication

Cite This Study

Interventions for enhancing medication adherence

Key Points

Discussion

Implication

Cite This Study

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