Objective: flower extract (CTE) on changes in serum protein carbonyls and urine 5-Hydroxyindoleacetic acid (5-HIAA) levels in those experiencing diabetic distress. Materials and Methods: A comparative study conducted with 30 healthy voluntaries as control group- CON, 90 type-2 diabetic patients experiencing moderate distress (as determined by a DDS-17 score between 2 and 3), 30 patients were assigned to either the DIAB, CTE-1 or CTE-2, with the CTE-1 group receiving 5 daily for 12 weeks and the CTE-2 group receiving 10 daily. Serum protein carbonyls and urinary 5-HIAA levels were assessed at the end of the twelfth week to conclude the preventive role of CTE on diabetic distress in the type-2 diabetic population. Results: Out of the 114 individuals initially enrolled in the study, 90 were included in the final analysis. The diabetic distress group (DIAB) exhibited significantly elevated levels of protein carbonyls and significantly decreased levels of 5-HIAA (p<0.001). In comparison to the CON group, the administration of both Shankhpushpi 5 g and 10 g extracts resulted in a significant reduction in serum protein carbonyls and an increase in urinary 5-HIAA, demonstrating a statistically significant compared with control (p<0.001). Conclusion: Shankhpushpi tea supplementation is beneficial in improvement of diabetic distress (quality of life) in diabetic patients.
Mani et al. (Tue,) studied this question.