Key result
Procainamide infusion significantly decreased atrial rate (498 vs 356 beats/min; p<0.005) and altered electrogram characteristics, causing up to 50% of segments to fail AF detection criteria.
Why the study?
Does procainamide alter intra-atrial electrograms and affect atrial fibrillation detection algorithms in patients with AF?
Population
8 patients with 11 episodes of atrial fibrillation
Comparison
Procainamide (50 mg/min iv, up to 1000 mg) vs Baseline (pre-procainamide infusion)
Design
Case_series
Follow-up
Continuous recordings before, during, and after infusion
Authors
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May impair AF detection by implantable devices; hypothesis-generating for algorithm adjustments in patients receiving procainamide.
Observational (n=8)
Does procainamide alter intra-atrial electrograms and affect atrial fibrillation detection algorithms in patients with AF?
Absolute Event Rate: 356% vs 498%
p-value: p=<0.005
Procainamide significantly alters intra-atrial electrograms during atrial fibrillation, potentially causing failure of arrhythmia-detection algorithms in implantable antitachycardia devices.
Ropella et al. (1988) conducted an observational in atrial fibrillation (n=8). procainamide vs. baseline (pre-procainamide) was evaluated on atrial rate (beats/min) (p=<0.005). Procainamide infusion significantly decreased atrial rate (498 vs 356 beats/min; p<0.005) and altered electrogram characteristics, causing up to 50% of segments to fail AF detection criteria.
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