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May 21, 2026PathogensOpen Access

Pathogenesis and Risk Factors of Post-Infectious Bronchiolitis Obliterans in Children: A Focus on Adenovirus and Mycoplasma Infections

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Authors

LZLing ZhuCMChenghao MeiCZChenchen Zhang

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Overview

Review analyzes pathogens leading to bronchiolitis obliterans in children, indicating critical knowledge gaps for better outcomes.

Key Points

  • This review aims to link acute immune activation to bronchiolar narrowing and evaluate PIBO risk factors.
  • Compares mechanistic pathways of HAdV and MP infections
  • Analyzes genetic susceptibility and epigenetic regulation in PIBO risk
  • Identifies knowledge gaps in single-cell studies and animal models
  • Both HAdV and MP converge on MyD88/NF-κB/MAPK signaling and neutrophil inflammation
  • Divergence in initial host engagement and inflammasome activation
  • Geographic variations exist in the importance of HAdV and MP for PIBO risk

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea17cbe05d6e3efb60300https://doi.org/10.3390/pathogens15050533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Narrative Review of the Pathophysiology of Post-Infectious Bronchiolitis Obliterans2026
  2. 2Post-infectious bronchiolitis obliterans in children: pathogenesis, treatment strategies, and future directions2026
  3. 3Outbreak of Post‐Infectious Bronchiolitis Obliterans (PIBO) After Adenovirus Infection: A Case Series and Review of the Literature2025 · 4 citations
  4. 4Postinfectious bronchiolitis obliterans in children: Clinical and pulmonary function findings2010 · 63 citations
  5. 5Post-Infectious Bronchiolitis Obliterans as a Model of Immune-Mediated Airway Fibrosis: A Pediatric Case Report2026 · 3 citations