Key result
Ischaemic preconditioning and carbenoxolone markedly reduced the total number of ventricular premature beats compared to controls (47±11 and 60±15 vs 440±104; P<0.05) in a canine model.
Why the study?
Does gap junction uncoupling via carbenoxolone or ischaemic preconditioning reduce ventricular arrhythmias in a canine model of ischaemia/reperfusion?
Population
60 dogs anaesthetised with chloralose and urethane, subjected to 25 or 60 min occlusion of the left anterior…
Comparison
Ischaemic preconditioning, 20 min intracoronary… vs Control dogs subjected to prolonged LAD…
Design
Preclinical
Follow-up
25 or 60 minutes of occlusion
Authors
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Leaves open clinical translation of gap junction uncoupling for arrhythmia prevention; extends mechanistic evidence for preconditioning in canine ischemia.
Does gap junction uncoupling via carbenoxolone or ischaemic preconditioning reduce ventricular arrhythmias in a canine model of ischaemia/reperfusion?
Absolute Event Rate: 47% vs 440%
p-value: p=<0.05
Gap junction uncoupling prior to ischaemia preserves electrical coupling and exerts an antiarrhythmic effect, suggesting partial closure of gap junctions triggers preconditioning protection.
Papp et al. (2007) studied Ischaemia/reperfusion arrhythmias (n=60). Ischaemic preconditioning (PC) or carbenoxolone (CBX) vs. Control was evaluated on Total number of ventricular premature beats (VPBs) (p=<0.05). Ischaemic preconditioning and carbenoxolone markedly reduced the total number of ventricular premature beats compared to controls (47±11 and 60±15 vs 440±104; P<0.05) in a canine model.
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