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October 13, 2000Circulation Research

During ischemia, Cx43 underwent progressive dephosphorylation with a time course similar to electrical uncoupling, alongside accumulation of nonphosphorylated Cx43 at intercellular junctions and translocation into intracellular pools.

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Population

Adult rat hearts perfused on a Langendorff apparatus

Comparison

Ischemia or ischemia/reperfusion vs Control hearts

Design

Preclinical

Authors

MBMichael A. BeardsleeDLDeborah LernerPTPeter N. Tadros

Discussion

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Overview

Associates Cx43 dephosphorylation with ischemic uncoupling in animals; leaves open whether targeting this alters human arrhythmia risk.

Structured PICO

P
Population
Adult rat hearts perfused on a Langendorff apparatus
I
Intervention
Ischemia or ischemia/reperfusion
C
Comparator
Control hearts
O
Outcome
Changes in coupling (measured by whole-tissue resistance) and changes in the amount and distribution of phosphorylated and nonphosphorylated isoforms of Cx43surrogate

Electrical uncoupling during acute myocardial ischemia is associated with the dephosphorylation and intracellular redistribution of the gap junction protein connexin43.

Cite This Study

Beardslee et al. (2000) studied this question.

synapsesocial.com/papers/6a705a5c26a7f98052dcdb54https://doi.org/10.1161/01.res.87.8.656
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heterogeneous Loss of Connexin43 Protein in Ischemic Dog Hearts1999 · 73 citations
  2. 2Effects of a reduction in the number of gap junction channels or in their conductance on ischemia-reperfusion arrhythmias in isolated mouse hearts2011 · 31 citations
  3. 3Gap junction heterogeneity in reentrant ventricular tachycardia2006 · 5 citations
  4. 4Connexin 43 Downregulation and Dephosphorylation in Nonischemic Heart Failure Is Associated With Enhanced Colocalized Protein Phosphatase Type 2A2004 · 205 citations
  5. 5Accelerated Onset and Increased Incidence of Ventricular Arrhythmias Induced by Ischemia in Cx43-Deficient Mice2000 · 272 citations