Design
Review
Key result
Gap junction uncoupling during acute cardiac ischemia impairs conduction and can initiate arrhythmias, though intermediate uncoupling may enhance the safety factor of propagation.
Authors
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May inform future antiarrhythmic strategies in acute ischemia; leaves open optimal gap junction modulation thresholds.
Understanding the role of gap junction uncoupling in ischemic arrhythmias may pave the way for new anti-arrhythmic therapeutic approaches.
Stefan Dhein (2006) conducted a review in Acute cardiac ischemia and infarction. Gap junction uncoupling was evaluated. Gap junction uncoupling during acute cardiac ischemia impairs conduction and can initiate arrhythmias, though intermediate uncoupling may enhance the safety factor of propagation.
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