Key result
Myocardial ischemia and infarction lead to the disorganization, reduction, and redistribution of connexin43 gap junctions, potentially contributing to contractile dysfunction and arrhythmogenesis.
Ischemia and infarction lead to early and persistent disorganization of myocardial gap junctions, which may underlie post-infarct arrhythmias and contractile dysfunction.
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May heighten post-ischemic arrhythmia vigilance; leaves open connexin43 modulation as a therapeutic target.
Nicholas S. Peters (1995) conducted a review in Myocardial ischemia and infarction. Myocardial ischemia and infarction lead to the disorganization, reduction, and redistribution of connexin43 gap junctions, potentially contributing to contractile dysfunction and arrhythmogenesis.
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