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August 31, 2006Cardiovascular ResearchOpen Access

Cardiac gap junctions are heterogeneously redistributed within the reentrant circuit in infarcted canine hearts, with increased lateralization of Cx43 protein restricted to the central common pathway.

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Population

5-day-old infarcted canine hearts with sustained ventricular tachycardia (referenced study)

Design

Editorial

Authors

RVRichard D. Veenstra

Discussion

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Overview

Does not yet alter post-MI VT management; leaves open whether Cx43 lateralization stabilizes reentry in patients.

Structured PICO

P
Population
5-day-old infarcted canine hearts with sustained ventricular tachycardia (referenced study)

Heterogeneous remodeling of cardiac gap junctions, particularly Cx43 lateralization, may help stabilize reentrant circuits and sustain ventricular tachycardia following myocardial infarction.

Cite This Study

Richard D. Veenstra (2006) studied this question.

synapsesocial.com/papers/6a7aabebf48aafa9d7f38f2bhttps://doi.org/10.1016/j.cardiores.2006.08.015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct☆2006 · 135 citations
  2. 2Atrial gap junction remodeling: Looking for lost gaps and orphaned connexins in three dimensions2006
  3. 3Myocardial gap junction organization in ischemia and infarction1995 · 52 citations
  4. 4Gap junction remodeling and cardiac arrhythmogenesis: cause or coincidence?2001 · 59 citations
  5. 5Remodelling of gap junctions and connexin expression in diseased myocardium2008 · 559 citations