Key result
Heterogeneous connexin43 expression across the ventricular wall, with 24% lower expression in subepicardial layers, was associated with reduced transmural conduction velocity (P<0.05).
Population
Left ventricles of eight dogs (canine wedge preparation)
Comparison
High-resolution transmural optical mapping and… vs Deeper layers of the ventricular wall
Design
Preclinical
Authors
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Supports heterogeneous Cx43 as arrhythmia substrate in animals; leaves open human relevance and requires prospective validation.
p-value: p=<0.05
Heterogeneous Cx43 expression across the ventricular wall is closely associated with functionally significant electrophysiological heterogeneities, potentially contributing to arrhythmic substrates.
Poelzing et al. (2004) studied Ventricular arrhythmias (n=8). Subepicardial vs deeper layer comparison vs. Deeper myocardial layers was evaluated on Relative Cx43 expression and transmural conduction velocity (p=<0.05). Heterogeneous connexin43 expression across the ventricular wall, with 24% lower expression in subepicardial layers, was associated with reduced transmural conduction velocity (P<0.05).
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