May 5, 2003Circulation ResearchOpen Access

Impulse Propagation in Synthetic Strands of Neonatal Cardiac Myocytes With Genetically Reduced Levels of Connexin43

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Population

Synthetic strands of cultured neonatal ventricular myocytes from Cx43+/+ and Cx+/- mice

Comparison

Heterozygote-null mutation of Cx43 (Cx43+/-) vs Wild type (Cx43+/+)

Design

Preclinical

Authors

STStuart P. ThomasThe University of Sydney JKJan KučeraUniversity of Bern LBLilly Bircher-LehmannWashington University in St. Louis

Discussion

Member takes

Implication

Challenges direct Cx43-conduction link in neonatal myocytes; hypothesis-generating for compensatory INa remodeling before clinical translation.

Structured PICO

Population

Synthetic strands of cultured neonatal ventricular myocytes from Cx43+/+ (wild type, WT) and Cx+/- (heterozygote, HZ) mice

Intervention

Heterozygote-null mutation of Cx43 (Cx43+/-)

Comparator

Wild type (Cx43+/+)

Outcome

Morphological and electrical properties including propagation velocity (theta), action potential amplitude, minimum diastolic potential, maximal upstroke velocity (dV/dtmax), and action potential durationsurrogate

A 43% reduction in Cx43 expression in neonatal ventricular myocytes does not reduce propagation velocity due to a compensatory increase in maximal upstroke velocity (dV/dtmax) driven by INa upregulation.

Cite This Study

Thomas et al. (2003) studied this question.

synapsesocial.com/papers/6a70a46a35aa2c282ce1f77a https://doi.org/10.1161/01.res.0000074916.41221.ea

View Full Paper

Ask AI

Bookmark

Implication

Challenges direct Cx43-conduction link in neonatal myocytes; hypothesis-generating for compensatory INa remodeling before clinical translation.

Impulse Propagation in Synthetic Strands of Neonatal Cardiac Myocytes With Genetically Reduced Levels of Connexin43

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impulse Propagation in Synthetic Strands of Neonatal Cardiac Myocytes With Genetically Reduced Levels of Connexin43

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider