The relative abundance of Cx43 and Cx40 determines atrial impulse propagation in neonatal hearts, with Cx43 dominance increasing and Cx40 dominance decreasing local propagation velocity.
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Connexin abundance modulates neonatal atrial conduction velocity; leaves open whether targeting Cx43/Cx40 alters human arrhythmia risk.
Beauchamp et al. (2006) studied this question.
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