Population
Preclinical model with deficient expression of Connexin43
Comparison
50% reduction in Connexin43 (Cx43) content vs Normal Connexin43 content
Design
Preclinical
Authors
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Cx43 reduction slows ventricular conduction in animals; leaves open chamber-specific roles in human arrhythmias.
Connexin43 and Connexin40 are chamber-specific determinants of myocardial conduction, with Cx43 being critical for ventricular conduction and Cx40 for atrial conduction.
Thomas et al. (1998) studied this question.