Population
Ventricular tissue from neonatal Cx43(+/+), Cx43(+/-) and Cx43(-/-) and adult Cx43(+/+) and Cx43(+/-) mice
Comparison
Cx43 deficiency (Cx43(+/-) and Cx43(-/-)) vs Wild-type control hearts (Cx43(+/+))
Design
Preclinical
Authors
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Cx43-dependent Cx45 localization may shape gap junction remodeling in genetic models; leaves open relevance to human arrhythmogenesis.
In Cx43-deficient mice, total Cx45 protein is not upregulated, but its localization to cardiac gap junctions is dramatically altered and dependent on Cx43 expression levels.
Carolyn M. Johnson (2002) studied this question.
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