January 1, 2001Cell Communication & Adhesion

Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart

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Why the study?

Does the loss of connexin43 (Cx43) function in the adult mouse heart contribute to arrhythmogenesis and ventricular dysfunction?

Structured PICO

Does the loss of connexin43 (Cx43) function in the adult mouse heart contribute to arrhythmogenesis and ventricular dysfunction?

Population

Murine models: heart-specific conditional knock-out (CKO) of connexin43 (Cx43) mice and chimeric mice formed from Cx43-null embryonic stem (ES) cells and wildtype recipient blastocysts.

Intervention

Genetic deletion of connexin43 (Cx43) via heart-specific conditional knock-out and generation of chimeric mice with heterogeneous Cx43 expression.

Outcome

Heart structure, contractile function, spontaneous ventricular arrhythmias, and sudden death.

Loss of connexin43 function in the adult mouse heart creates an arrhythmogenic substrate leading to sudden death and contributes to contractile dysfunction.

Discussion

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Implication

Cx43 loss precipitates arrhythmias and dysfunction in mice; leaves open its role in human arrhythmogenesis and HF.

Cite This Study

Gutstein et al. (2001) studied this question.

synapsesocial.com/papers/6a708e54e71d69abee08af72 https://doi.org/10.3109/15419060109080751

Topics

Ventricular arrhythmias

View Full Paper

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Bookmark

Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart

Structured PICO

Discussion

Implication

Cite This Study

Topics

Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider