Key result
Heterogeneous Cx43 expression in chimeric mice significantly reduced fractional shortening (26.6% vs 36.5%; P<0.05) and caused highly irregular epicardial conduction patterns.
Why the study?
Does heterogeneous Cx43 expression cause conduction defects and depress cardiac performance in a murine model?
Population
Murine model of heterogeneous gap junction channel expression, n=12
Comparison
Heterogeneous connexin43 (Cx43) expression vs Age-matched 129/SvxC57BL/6F1 wild-type controls
Design
Preclinical
Authors
Loading...
Supports Cx43 heterogeneity as a driver of conduction and contractile defects; leaves open relevance to clinical heart disease.
Does heterogeneous Cx43 expression cause conduction defects and depress cardiac performance in a murine model?
Absolute Event Rate: 26.6% vs 36.5%
p-value: p=<0.05
Heterogeneous expression of Cx43 gap junctions in a murine model directly causes conduction defects and depresses cardiac contractile function.
Gutstein et al. (2001) studied Conduction defects and ventricular dysfunction (n=12). Heterogeneous Cx43 expression (chimeric mice) vs. Wild-type controls was evaluated on Fractional shortening (p=<0.05). Heterogeneous Cx43 expression in chimeric mice significantly reduced fractional shortening (26.6% vs 36.5%; P<0.05) and caused highly irregular epicardial conduction patterns.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: