Why the study?
Does knockout of Cx43 alter intercellular electrical conductance and propagation velocity in ventricular myocyte strands?
Population
Synthetic strands and pairs of ventricular myocytes from germline Cx43-/-, Cx43+/-, and wild-type mice
Comparison
Germline knockout of connexin43 (Cx43-/-) vs Wild-type and heterozygous ventricular myocytes
Design
Preclinical
Authors
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Cx43 knockout severely impairs ventricular conduction in murine strands; extends gap-junction insights but leaves open human arrhythmogenic relevance.
Does knockout of Cx43 alter intercellular electrical conductance and propagation velocity in ventricular myocyte strands?
Knockout of Cx43 in ventricular myocytes leads to severely reduced intercellular conductance and very slow, discontinuous electrical propagation dependent on residual Cx45.
Beauchamp et al. (2004) studied this question.
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