Key result
Cardiac-restricted inactivation of connexin43 in mice severely reduced junctional coupling to 4-11 nS compared to 558-588 nS in controls, suggesting additional mechanisms maintain in vivo conduction.
Why the study?
Does cardiac-restricted inactivation of the connexin43 gene alter gap junctional conductance in murine ventricular myocyte pairs?
Population
Ventricular myocyte pairs from mice with cardiac-restricted inactivation of the connexin43 gene and control…
Comparison
Cardiac-restricted inactivation of the… vs Control cell-pairs
Design
Preclinical
Authors
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Questions necessity of Cx43 for ventricular propagation; leaves open compensatory mechanisms in vivo.
Does cardiac-restricted inactivation of the connexin43 gene alter gap junctional conductance in murine ventricular myocyte pairs?
The severe reduction in gap junctional conductance in Cx43-deficient mice suggests that additional mechanisms must exist to maintain cardiac propagation in vivo.
Yao et al. (2003) studied Connexin43-deficient murine hearts. Cardiac-restricted inactivation of the connexin43 gene vs. Control cell-pairs was evaluated on Gap junctional conductance in ventricular pairs. Cardiac-restricted inactivation of connexin43 in mice severely reduced junctional coupling to 4-11 nS compared to 558-588 nS in controls, suggesting additional mechanisms maintain in vivo conduction.
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