Key result
Occlusion of the proximal LAD in a feline model led to ventricular tachycardia degenerating to ventricular fibrillation in 4 of 15 animals, driven primarily by continued intramural reentry.
Population
15 feline hearts in vivo
Design
Preclinical
Follow-up
1-5 minutes
Authors
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Does not change clinical management of acute ischemia; leaves open intramural reentry as VF driver pending human validation.
In a feline model of early myocardial ischemia, the transition from ventricular tachycardia to ventricular fibrillation is driven by continued intramural reentry and rapid recovery of excitability.
Pogwizd et al. (1990) studied Early myocardial ischemia (n=15). Occlusion of the proximal left anterior descending coronary artery was evaluated on Development of ventricular fibrillation. Occlusion of the proximal LAD in a feline model led to ventricular tachycardia degenerating to ventricular fibrillation in 4 of 15 animals, driven primarily by continued intramural reentry.
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