Key result
Occlusion of the proximal LAD in a feline model led to ventricular tachycardia degenerating to ventricular fibrillation in 4 of 15 animals, driven primarily by continued intramural reentry.
In a feline model of early myocardial ischemia, the transition from ventricular tachycardia to ventricular fibrillation is driven by continued intramural reentry and rapid recovery of excitability.
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Does not change clinical management of acute ischemia; leaves open intramural reentry as VF driver pending human validation.
Pogwizd et al. (1990) studied Early myocardial ischemia (n=15). Occlusion of the proximal left anterior descending coronary artery was evaluated on Development of ventricular fibrillation. Occlusion of the proximal LAD in a feline model led to ventricular tachycardia degenerating to ventricular fibrillation in 4 of 15 animals, driven primarily by continued intramural reentry.