Key result
Sotalol prevented or significantly slowed ventricular arrhythmias in 58% of studies compared to 7% with metoprolol in conscious dogs post-myocardial infarction.
Absolute Event Rate: 58% vs 7%
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Sotalol outperforms metoprolol in this post-MI canine model; extends preclinical support for sotalol but warrants human RCTs before clinical adoption.
Cobbe et al. (1983) studied Postmyocardial infarction with ventricular arrhythmias (n=17). Sotalol vs. Metoprolol was evaluated on Prevention or significant slowing of ventricular arrhythmias. Sotalol prevented or significantly slowed ventricular arrhythmias in 58% of studies compared to 7% with metoprolol in conscious dogs post-myocardial infarction.
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