December 1, 2004Journal of the American Society of Nephrology
A Comparison of Iothalamate-GFR and Serum Creatinine-Based Outcomes
Key result
Outcomes based on serum creatinine and iothalamate GFR yielded similar main trial conclusions regarding the effects of interventions in patients with hypertensive nephrosclerosis.
Why the study?
Do renal outcomes based on serum creatinine yield similar trial conclusions compared to outcomes based on iothalamate GFR in patients with hypertensive nephrosclerosis?
Population
1094 African Americans with hypertensive nephrosclerosis from the African American Study of Kidney Disease…
Comparison
Renal outcomes based on serum creatinine vs Renal outcomes based on iothalamate GFR (iGFR)
Design
Cohort
Authors
Discussion
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Implication
Serum creatinine-based eGFR may suffice for renal outcome trials in hypertensive nephrosclerosis; leaves open validation in other populations and endpoints.
Study Design
Type
Observational (n=1,094)
Structured PICO
Do renal outcomes based on serum creatinine yield similar trial conclusions compared to outcomes based on iothalamate GFR in patients with hypertensive nephrosclerosis?
P
Population
1094 African Americans with hypertensive nephrosclerosis from the African American Study of Kidney Disease and Hypertension (AASK) trial
I
Intervention
Renal outcomes based on serum creatinine (estimated GFR)
C
Comparator
Renal outcomes based on iothalamate GFR (iGFR)
O
Outcome
Comparison of the effects of trial interventions on outcomes based on serum creatinine versus corresponding outcomes based on iGFRsurrogate
Serum creatinine-based estimated GFR yields similar overall trial conclusions to iothalamate GFR, supporting its use in the design of clinical trials with renal outcomes.
Cite This Study
Lewis et al. (2004) conducted an observational in hypertensive nephrosclerosis (n=1,094). iothalamate GFR (iGFR)-based outcomes vs. serum creatinine-based outcomes was evaluated on Time-to-event composite outcomes (GFR decline/doubling of serum creatinine, ESRD, or death) and GFR slopes. Outcomes based on serum creatinine and iothalamate GFR yielded similar main trial conclusions regarding the effects of interventions in patients with hypertensive nephrosclerosis.