Key result
Off-pump coronary artery bypass grafting combined with factor VIII/von Willebrand factor concentrate administration successfully prevented excessive bleeding in a patient with type 1 von Willebrand disease.
Why the study?
Does off-pump coronary artery bypass grafting combined with factor VIII/VWF concentrate replacement prevent bleeding complications in a patient with type 1 von Willebrand disease requiring surgical myocardial revascularization?
Case Report (n=1)
No
Does off-pump coronary artery bypass grafting combined with factor VIII/VWF concentrate replacement prevent bleeding complications in a patient with type 1 von Willebrand disease requiring surgical myocardial revascularization?
Off-pump coronary artery bypass grafting combined with factor VIII/VWF concentrate replacement is a safe and effective strategy to prevent bleeding complications in patients with von Willebrand disease requiring surgical myocardial revascularization.
Cardiac surgery in patients with preexisting bleeding disorders can be a challenge. Cardiopulmonary bypass can lead to bleeding disorders, above all in patients with coagulopathy. We report the case of a 42-year-old woman, with type I von Willebrand disease, who underwent off-pump coronary artery bypass grafting. Beating heart surgery associated with an adequate replacement of von Willebrand factor and factor VIII levels were chosen to prevent bleeding disorders. Her postoperative course was uneventful and she was discharged home after 5 postoperative days.
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Cristodoro et al. (2015) conducted a case report in Type 1 von Willebrand disease and severe coronary artery disease (n=1). Off-pump coronary artery bypass grafting (OPCABG) and VIII/VWF concentrate was evaluated on Prevention of excessive bleeding and successful surgical revascularization. Off-pump coronary artery bypass grafting combined with factor VIII/von Willebrand factor concentrate administration successfully prevented excessive bleeding in a patient with type 1 von Willebrand disease.
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