December 10, 2013Heart
Exercise capacity and paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy
Key result
Paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy was significantly associated with exercise intolerance compared to those without AF (OR 4.65; 95% CI 1.83-11.83; p=0.001).
Why the study?
Is paroxysmal atrial fibrillation associated with exercise intolerance in patients with hypertrophic cardiomyopathy?
Population
265 patients with hypertrophic cardiomyopathy who underwent symptom-limited cardiopulmonary testing with…
Comparison
Paroxysmal atrial fibrillation vs No atrial fibrillation
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May warrant AF evaluation in HCM exercise testing; leaves open whether rhythm control improves capacity.
Study Design
Type
Observational (n=265)
Multicenter
No
Structured PICO
Is paroxysmal atrial fibrillation associated with exercise intolerance in patients with hypertrophic cardiomyopathy?
P
Population
265 patients with hypertrophic cardiomyopathy (HCM) who underwent symptom-limited cardiopulmonary testing with expired gas analysis
I
Intervention
Paroxysmal atrial fibrillation (observational exposure)
C
Comparator
No atrial fibrillation
O
Outcome
Exercise intolerance (defined as peak VO2 < 20 mL/kg/min)surrogate
Main Result
Effect estimate: OR 4.65 (95% CI 1.83-11.83)
Absolute Event Rate: 61% vs 28%
p-value: p=0.001
In patients with hypertrophic cardiomyopathy, a history of paroxysmal atrial fibrillation is independently associated with significant exercise intolerance, even when patients are in sinus rhythm during testing.
Cite This Study
Azarbal et al. (2013) conducted an observational in Hypertrophic cardiomyopathy (n=265). Paroxysmal atrial fibrillation vs. No atrial fibrillation was evaluated on Exercise intolerance (peak VO2 < 20 mL/kg/min) (OR 4.65, 95% CI 1.83-11.83, p=0.001). Paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy was significantly associated with exercise intolerance compared to those without AF (OR 4.65; 95% CI 1.83-11.83; p=0.001).