What question did this study set out to answer?

To delineate the direct and indirect anatomical projections between the amygdala and various subregions of the frontal cortex in primates.

May 1, 1981The Journal of Comparative Neurology

Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys

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Authors

LPLinda J. PorrinoWake Forest University ACAlison M. CraneUniversity of Georgia PGP.S. Goldman-RakicYale University

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Implication

Neuroanatomical tracing study reveals selective direct and indirect amygdala projections targeting ventromedial frontal cortex in rhesus monkeys, highlighting a distinct limbic frontal division.

Key Points

To delineate the direct and indirect anatomical projections between the amygdala and various subregions of the frontal cortex in primates.
Conducted retrograde axonal tracing via injections of horseradish peroxidase (HRP) into multiple frontal regions, including orbital prefrontal cortex, gyrus rectus, superior frontal gyrus, anterior cingulate gyrus, principal sulcus, and lateral inferior convexity in rhesus monkeys.
Performed anterograde autoradiographic tracing using tritiated amino acid injections into the amygdala to identify direct terminal fields and pathways traversing the magnocellular mediodorsal thalamic nucleus (MDmc).
Direct projections from the basolateral, basomedial, and basal accessory nuclei of the amygdala terminated selectively in orbital cortex and gyrus rectus (layer 1) as well as the superior prefrontal and anterior cingulate gyri (layer 2), completely sparing dorsolateral prefrontal areas.
Tritiated tracer injections confirmed an indirect projection to the magnocellular mediodorsal thalamus, which innervates the identical ventromedial frontal fields primarily at layer 3 and superficial layer 1.
The findings demonstrate a structural dichotomy in the primate frontal lobe, isolating a ventromedial 'limbic' association cortex receiving dual amygdaloid inputs from an amygdala-devoid dorsolateral region.

Cite This Study

Porrino et al. (1981) studied this question.

synapsesocial.com/papers/6a0ea7dba14f152feaf9aab8 https://doi.org/10.1002/cne.901980111

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Implication

Neuroanatomical tracing study reveals selective direct and indirect amygdala projections targeting ventromedial frontal cortex in rhesus monkeys, highlighting a distinct limbic frontal division.

Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys

Discussion

Member takes

Implication

Key Points

Cite This Study

Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys

Discussion

Member takes

Implication

Key Points

Cite This Study

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