Key result
Straight deep hypothermic circulatory arrest is an effective and safe cerebral protection technique for aortic arch surgery, achieving an overall mortality rate of 2.2% and a stroke rate of 3.1%.
Why the study?
Does deep hypothermic circulatory arrest (DHCA) provide effective cerebral protection compared to other perfusion strategies in patients undergoing aortic arch surgery?
Does deep hypothermic circulatory arrest (DHCA) provide effective cerebral protection compared to other perfusion strategies in patients undergoing aortic arch surgery?
Despite the rise of antegrade cerebral perfusion, straight deep hypothermic circulatory arrest remains a convenient, simple, and effective strategy for cerebral protection during aortic arch surgery.
Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes, necessitating the adjunctive use of antegrade (ACP) and retrograde cerebral perfusion (RCP). ACP has superseded RCP as the preferred perfusion strategy as it most closely mimic physiological perfusion, although there exists uncertainty regarding several technical details, such as unilateral versus bilateral perfusion, flow rate and temperature, perfusion site, undue trauma to head vessels, and risks of embolization. Nevertheless, we believe that the convenience, simplicity and effectiveness of straight DHCA justifies its use in the majority of elective and emergency cases. The following perspective offers a historical and clinical comparison of the DHCA with other techniques of cerebral protection.
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Ziganshin et al. (2013) conducted a review in Aortic arch aneurysm (n=394). Straight deep hypothermic circulatory arrest (DHCA) vs. Antegrade cerebral perfusion (ACP) and Retrograde cerebral perfusion (RCP) was evaluated on Mortality rate (all cases). Straight deep hypothermic circulatory arrest is an effective and safe cerebral protection technique for aortic arch surgery, achieving an overall mortality rate of 2.2% and a stroke rate of 3.1%.
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