Key result
Elevated NAP-2 and 3-nitrotyrosine are linked to LV remodeling and hypertrophy in AF.
Why the study?
AF coexists with LV dysfunction and remodeling, while neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.
Cross-Sectional (n=221)
Elevated plasma levels of NAP-2 and 3-nitrotyrosine are associated with concentric and eccentric left ventricular hypertrophy in patients with atrial fibrillation, suggesting a role for neutrophil activation and oxidative stress in cardiac remodeling.
Answers are grounded in this paper and cite their sources.
Should not yet change AF management; hypothesis-generating for NAP-2 and oxidative stress in LV remodeling.
Background Atrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling.Materials and methods In 221 AF patients aged 70 (62–76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.Results AF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%, p = 0.001 and p = 0.025, respectively). Moreover, concentric hypertrophy was associated with 85% higher 3-nitrotyrosine level (p = 0.01) compared to normal LV geometry.Conclusions Elevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.
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Mołek et al. (2025) conducted a cross-sectional in Atrial fibrillation (n=221). Left ventricular hypertrophy (concentric and eccentric) vs. Normal left ventricular geometry was evaluated on Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine (+41% (concentric) and +29% (eccentric) for NAP-2; +85% (concentric) for 3-nitrotyrosine, p=0.001). Concentric and eccentric LV hypertrophy in AF patients were associated with higher NAP-2 (+41%, p=0.001; +29%, p=0.025) and 3-nitrotyrosine (+85% in concentric, p=0.01) vs normal geometry.
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