Key result
Angiotensin II infusion at sub-pressor doses in rats decreased the vascular relaxant response to acetylcholine sixfold and promoted endothelial peroxynitrite formation.
Authors
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Should not change hypertension management; hypothesis-generating for peroxynitrite as endothelial target in humans.
Effect estimate: decreased sixfold
Wattanapitayakul et al. (2000) studied Angiotensin-induced cardiovascular disorders. Angiotensin II (ANG II) vs. Control group was evaluated on Vascular relaxant response to acetylcholine (ACh) and 3-nitrotyrosine immunoreactivity (decreased sixfold). Angiotensin II infusion at sub-pressor doses in rats decreased the vascular relaxant response to acetylcholine sixfold and promoted endothelial peroxynitrite formation.
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