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September 20, 1985Science

Spatially Regulated Expression of Homeotic Genes in Drosophila

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Authors

KHKatherine HardingHarvard UniversityCWCathy J. WedeenNew York Medical CollegeWMWilliam McGinnisUniversity of California, San Diego

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Implication

Gene expression analysis reveals discrete, nonoverlapping central nervous system expression of homeotic genes in Drosophila embryos, suggesting hierarchical cross-regulatory control.

Key Points

  • To identify the spatial patterns of transcript accumulation for six homeotic loci within the Antennapedia and bithorax gene complexes in developing Drosophila embryos.
  • Examined six Antennapedia-class homeobox gene loci from the Antennapedia (ANT-C) and bithorax (BX-C) complexes.
  • Mapped spatial transcript accumulation across embryo tissue sections using in situ hybridization.
  • Transcripts for each of the six loci accumulated primarily in discrete, nonoverlapping domains of the embryonic central nervous system (CNS).
  • The spatial distribution of transcripts in the CNS mapped directly to the specific embryonic segments disrupted in corresponding homeotic mutant flies.

Cite This Study

Harding et al. (1985) studied this question.

synapsesocial.com/papers/6a0eaa7aa14f152feaf9ae94https://doi.org/10.1126/science.3898362
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Also Consider

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  3. 3HOMOEOSIS IN DROSOPHILA. I. COMPLEMENTATION STUDIES WITH REVERTANTS OF NASOBEMIA1973 · 58 citations