Key result
Surgical myectomy linked to a ~73% reduction in LVOT gradient in HOCM patients.
Why the study?
The study aimed to evaluate the effect of myomectomy and its impact on survival for a period of 1 year.
Does surgical myectomy improve LVOT gradient and survival in patients with hypertrophic obstructive cardiomyopathy?
Observational (n=21)
No
Does surgical myectomy improve LVOT gradient and survival in patients with hypertrophic obstructive cardiomyopathy?
Surgical myectomy effectively reduces left ventricular outflow tract obstruction in patients with hypertrophic obstructive cardiomyopathy.
May support myectomy for gradient relief in HOCM; leaves survival benefit unconfirmed in randomized trials.
Background: Hypertrophic cardiomyopathy is highly heterogeneous with a diverse anatomy, pathophysiology, and clinical course. It is obstruction to left ventricular outflow that has become the major hallmark of the disease. Septal myectomy has been the gold standard treatment for the relief of left ventricular outflow tract obstruction and cardiac symptoms in both adults and children with obstructive hypertrophic cardiomyopathy. Objective of the study was to evaluate effect of Myomectomy and its impact on survival for a period of one year.Methods: The study design is a retrospective record based observational study. Data was retrieved from previous records both electronic as well as manual records of all the patients who underwent myectomy with or without concomitant procedures such as mitral valve replacement or aortic valve replacement or coronary artery bypass surgery during 2014 to 2018.Results: Majority of the patients 11 (52.4%) in fourth decade i.e. 40-59 years age group. majority were males i.e. 16 (76.2%) and remaining 5 i.e. 23.8% were females. Male to female ratio was 3.2:1. Dyspnoea was present 81% and chest pain in 76.2%. Preoperative LVOT gradient was 86.86±20.33 and post-operative gradient was 23.47±20.49.Conclusions: Operative techniques have evolved from simple myotomy to the present method of extended septal myectomy which can be done in all adult cases of hypertrophic obstructive cardiomyopathy.
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Gopalan et al. (2020) conducted an observational in Hypertrophic obstructive cardiomyopathy (n=21). Surgical myectomy vs. Pre-operative baseline was evaluated on Left ventricular outflow tract (LVOT) gradient. Surgical myectomy effectively reduced the mean left ventricular outflow tract gradient from 86.86 to 23.47 in patients with hypertrophic obstructive cardiomyopathy.
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