Key result
Preoperative aspirin is linked to ~77% higher RBC transfusion odds but not more bleeding re-operations.
Why the study?
Does preoperative aspirin use within 5 days of surgery increase bleeding and transfusion requirements in patients undergoing cardiac surgery?
Population
728 adults undergoing CABG, valve, or combined CABG and valve surgery at a single academic medical center…
Comparison
Aspirin administered within 5 days prior to… vs No aspirin use within 5 days prior to surgery
Design
Cohort
Follow-up
5 days postoperatively
Authors
Loading...
May increase transfusion risk without major bleeding; leaves open need for randomized confirmation before changing perioperative aspirin guidance.
Cohort (n=728)
No
Does preoperative aspirin use within 5 days of surgery increase bleeding and transfusion requirements in patients undergoing cardiac surgery?
Effect estimate: OR 1.77 (95% CI 1.07, 2.95)
Absolute Event Rate: 61.9% vs 55.2%
p-value: p=0.027
Preoperative aspirin within 5 days of cardiac surgery increases the likelihood of RBC transfusion but does not significantly increase major bleeding complications like re-operation or chest tube drainage.
Goldhammer et al. (2015) conducted a cohort in Cardiac surgery (CABG, valve, or combined) (n=728). Preoperative aspirin vs. No preoperative aspirin was evaluated on Red blood cell (RBC) transfusion (OR 1.77, 95% CI 1.07, 2.95, p=0.027). Preoperative aspirin use within 5 days of cardiac surgery was associated with an increased probability of receiving a red blood cell transfusion (adjusted OR 1.77) but not with increased re-operation for bleeding.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: