Key result
Clopidogrel plus ASA completely prevented positive exercise tests and graft occlusion at 6 months compared to a 35% incidence with ASA alone in patients with post-CABG reactive thrombocytosis.
Why the study?
Does clopidogrel added to acetylsalicylic acid improve graft patency in patients with reactive thrombocytosis after CABG?
Population
60 patients who underwent coronary artery bypass grafting operation, including 40 who developed reactive…
Comparison
Clopidogrel 75 mg/day oral added to… vs Acetylsalicylic acid (ASA) 300 mg/day oral alone
Design
RCT, Patients who developed reactive thrombocytosis were randomized into group…
Follow-up
6 months
Authors
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May support dual antiplatelet therapy for graft patency in post-CABG thrombocytosis; hypothesis-generating and requires randomized confirmation before practice change.
RCT (n=60)
Randomized
No
Does clopidogrel added to acetylsalicylic acid improve graft patency in patients with reactive thrombocytosis after CABG?
Absolute Event Rate: 0% vs 35%
p-value: p=<.01
Kayacıoğlu et al. (2008) conducted an RCT in Reactive thrombocytosis after coronary artery bypass grafting (CABG) (n=60). Clopidogrel and Acetylsalicylic acid (ASA) vs. ASA 300 mg/day alone was evaluated on Positive exercise test indicating potential graft occlusion at 6 months (p=<.01). Clopidogrel plus ASA completely prevented positive exercise tests and graft occlusion at 6 months compared to a 35% incidence with ASA alone in patients with post-CABG reactive thrombocytosis.
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