Key result
This review provides a comprehensive overview of endothelial dysfunction in atrial fibrillation and the methods used to assess it.
This review provides an overview of the pathophysiological mechanisms linking endothelial dysfunction to atrial fibrillation and thromboembolism, alongside methods for its assessment.
May guide future endothelial-targeted AF research; leaves open any role in clinical risk stratification or therapy.
Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mechanism(s) relating endothelial (dys)function to AF and thromboembolism are yet to be fully elucidated. This review article aims to provide a comprehensive overview of endothelial (dys)function and AF, as well as the merits and limitations of the different methods used to assess endothelial function in AF.
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Krishnamoorthy et al. (2009) conducted a review in Atrial fibrillation. This review provides a comprehensive overview of endothelial dysfunction in atrial fibrillation and the methods used to assess it.
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