Key result
Sample size calculations must be performed at the design stage of clinical studies to ensure adequate statistical power and prevent falsely concluding an absence of effect.
Design
Review
Authors
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Risk of false negatives from underpowered studies persists; leaves open optimal methods for critical care designs.
Whitley et al. (2002) reported a review. Sample size calculations must be performed at the design stage of clinical studies to ensure adequate statistical power and prevent falsely concluding an absence of effect.
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