What question did this study set out to answer?

To investigate the relationships between gut bacterial community composition, lung function, and clinical phenotypic features in adults with established asthma.

September 1, 2018BMJ Open Respiratory ResearchOpen Access

Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study

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Authors

LBLesa BegleyUniversity of Michigan SMSiddharth MadapoosiGeorgetown University KOKristopher OpronUniversity of Michigan

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Implication

Prospective cohort study observes links between gut microbiota composition and lung function in adults with asthma, suggesting intestinal bacteria associate with airway disease phenotypes.

Key Points

To investigate the relationships between gut bacterial community composition, lung function, and clinical phenotypic features in adults with established asthma.
Analyzed 58 fecal samples from 32 adults (24 with asthma and 8 without asthma) enrolled in a prospective observational cohort study at the University of Michigan.
Characterized gut bacterial community structure and paired sample stability using 16S ribosomal RNA gene sequencing.
Assessed associations between microbial community profiles and clinical parameters, including aeroallergen sensitization and lung function.
Differences in gut bacterial community structure were significantly associated with aeroallergen sensitization and forced expiratory volume in 1 s (FEV1) percent predicted across multiple analytic methods.
K-means clustering of microbiota data in adults with asthma identified three distinct subgroups that differed significantly by FEV1 (p < 0.05) alongside trends in clinical and inflammatory markers.

Cite This Study

Begley et al. (2018) studied this question.

synapsesocial.com/papers/6a0eb66fb7cc3b883f22a918 https://doi.org/10.1136/bmjresp-2018-000324

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Implication

Prospective cohort study observes links between gut microbiota composition and lung function in adults with asthma, suggesting intestinal bacteria associate with airway disease phenotypes.

Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

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