Why the study?
TAVR is widely used for aortic stenosis, where anchoring of most transcatheter heart valves depends on friction with the native aortic valve.
Does TAVR using the Xcor system with transapical access improve clinical and echocardiographic outcomes in patients with severe aortic stenosis?
Observational (n=9)
No
Does TAVR using the Xcor system with transapical access improve clinical and echocardiographic outcomes in patients with severe aortic stenosis?
The novel Xcor transapical TAVR system appears safe and feasible for severe aortic stenosis, significantly improving hemodynamics and functional status at 30 days in a small early cohort.
Background: Transcatheter aortic valve replacement (TAVR) has been widely used to treat patients with aortic stenosis (AS). The anchoring of most transcatheter heart valves (THV) depends on friction with the native aortic valve (AV). Methods: A total of 9 patients with severe AS accepted TAVR using Xcor system with transapical access in our center. Clinical outcomes were collected at baseline, before discharge, and at the 30-day follow-up. Results: All patients achieved procedural success, postprocedural transesophageal echocardiography showed that all of the patients had no/trace paravalvular leakage. The mean AV pressure gradient decreased from 50 mmHg (range 18-76 mmHg) to 10 mmHg (range 8-14 mmHg) ( P < .001). At the 30-day follow-up, all patients had an improvement of ⩾1 New York Heart Association functional class ( P < .001). The average 6-minute walk distance (377.2 [range 330.0-430.0] m vs 276.1 [range 245.0-320.0] m, P < .001) and Kansas City cardiomyopathy questionnaire score (53.4 [range 45.0-62.0] vs 38.9 [range 35.0-43.0], P < .001) were both improved. Conclusions: Our early experience shows that the Xcor system is safe and feasible in the treatment of patients with severe AS.
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Jin et al. (2025) conducted an observational in Severe aortic stenosis (n=9). Xcor System (transapical transcatheter aortic valve replacement) was evaluated on Mean aortic valve pressure gradient (mmHg) (p=<0.001).
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