A negative T‐wave in electrocardiogram at 50 years predicted lifetime mortality in a random population‐based cohort
Key result
Negative T-waves on ECG at age 50 linked to ~59% higher lifetime mortality risk.
- HR 1.59
- 95% CI 1.20-2.11
- P=.0012
- n=839
Why the study?
Severe ECG abnormalities in asymptomatic subjects correlate with cardiovascular risk, but the role of minor ECG abnormalities such as a negative T-wave is less well-known.
Does the presence of a negative T-wave on ECG predict all-cause and cardiovascular mortality in asymptomatic 50-year-old individuals?
Population
839 asymptomatic participants examined at 50 years
Comparison
Presence vs absence of a negative T-wave on ECG
Design
Prospective population-based cohort study
Follow-up
Until death
Authors
Discussion
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Member takes
Implication
May warrant ECG review in midlife risk assessment; extends observational prognostic data but leaves clinical utility open.
Study Design
Type
Cohort (n=839)
Structured PICO
Does the presence of a negative T-wave on ECG predict all-cause and cardiovascular mortality in asymptomatic 50-year-old individuals?
P
Population
839 asymptomatic individuals from a random prospective population-based cohort, examined at 50 years of age.
I
Intervention
Presence of a negative T-wave on electrocardiogram (ECG)
C
Comparator
Absence of a negative T-wave on electrocardiogram (ECG)
O
Outcome
All-cause and cardiovascular (CV) death during lifetime follow-uphard clinical
Main Result
Effect estimate: HR 1.59 (95% CI 1.20-2.11)
p-value: p=.0012
A negative T-wave on ECG in asymptomatic 50-year-olds is an independent predictor of lifetime all-cause and cardiovascular mortality.
Cite This Study
Sjöland et al. (2020) conducted a cohort in Asymptomatic individuals (n=839). Negative T-wave on electrocardiogram vs. Without negative T-wave was evaluated on All-cause death (HR 1.59, 95% CI 1.20-2.11, p=.0012). A negative T-wave on ECG at age 50 in asymptomatic individuals was associated with an increased risk of all-cause death (HR 1.59; 95% CI 1.20-2.11; P=0.0012) during lifetime follow-up.