Key result
Pediatric DCM carries up to ~67% mortality at five years, demanding early etiology-specific management.
Why the study?
Dilated cardiomyopathy in children has a broad differential diagnosis making diagnosis and management difficult, requiring clear guidance on etiologies, diagnostic modalities, and therapeutic implications.
This review highlights the diverse etiologies, diagnostic approaches, and management strategies for pediatric dilated cardiomyopathy, emphasizing the importance of early detection and etiology-specific treatment.
Supports etiology-specific care in pediatric DCM; leaves open optimal protocols for prospective validation.
Dilated cardiomyopathy (DCM) is a common cardiac diagnosis in children that may result as a consequence of diverse genetic and environmental insults. The differential diagnosis remains quite broad and as a result the approach to diagnosis and management may, at times, be quite difficult. A rigorous work-up can exclude alternative causes of left ventricular (LV) dilation and dysfunction, identify etiologies that may respond to specific treatments, and guide family screening. Assessment of myocardial detection of pre-clinical DCM could significantly reduce morbidity and mortality by allowing early instigation of cardio protective therapy. This review article discusses genetic and acquired causes of DCM, diagnostic modalities and therapeutic implications in the hope of informing physicians of a clinical entity that afflicts a substantial number of children worldwide. Cardiovasc. j. 2019; 12(1): 64-74
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Fatema et al. (2019) conducted a review in Dilated Cardiomyopathy. Dilated cardiomyopathy in children is a diverse disorder with a 5-year mortality of 33% to 67%, requiring early identification and etiology-specific management to improve outcomes.
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