Key result
Maintaining adequate vitamin D appears crucial for preventing obesity-related cardiometabolic complications by regulating adipose tissue.
Why the study?
Obesity-associated adipose tissue dysfunction drives metabolic disorders, and emerging evidence highlights the vitamin D/vitamin D receptor axis as an important regulator of adipose tissue homeostasis.
This review highlights the potential role of the vitamin D/vitamin D receptor axis in regulating adipose tissue homeostasis and mitigating obesity-related cardiometabolic complications.
This is the authors' abstract. We don't add key points for this paper.
Obesity-associated adipose tissue dysfunction represents a key driver of metabolic disorders, including type 2 diabetes, cardiovascular diseases, and fatty liver disease. Emerging evidence highlights the vitamin D/vitamin D receptor (VD/VDR) axis as an important regulator of adipose tissue homeostasis. Beyond its classical role in mineral metabolism, vitamin D influences adipogenesis, inflammation, and insulin sensitivity, thereby modulating systemic metabolic health. In this review, we summarize the current understanding of the VD/VDR axis in adipose tissue biology, from molecular pathways controlling lipid turnover and immune responses to experimental and clinical evidence linking vitamin D status with obesity-related complications. We also discuss the role of genetic variability and tissue-specific VDR signaling in shaping metabolic outcomes. While results from supplementation trials remain inconsistent, maintaining adequate vitamin D levels appears crucial for the prevention of adipose tissue dysfunction and its cardiometabolic consequences. Future studies are warranted to define optimal strategies for harnessing the VD/VDR axis in therapeutic approaches to obesity and metabolic disease.
Hypothesis-generating for vitamin D/VDR in obesity-related cardiometabolic risk; RCTs needed before clinical adoption.
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Cimini et al. (2025) conducted a review in Obesity-associated adipose tissue dysfunction and metabolic diseases. Vitamin D/Vitamin D Receptor (VD/VDR) axis was evaluated. The vitamin D/vitamin D receptor axis regulates adipose tissue homeostasis, and maintaining adequate vitamin D levels appears crucial for preventing obesity-related cardiometabolic complications.
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