Cardiac troponin I levels ≥0.4 ng/mL were associated with significantly higher 42-day mortality compared to levels <0.4 ng/mL (3.7% vs 1.0%, P<0.001) in patients with acute coronary syndromes.
Cohort (n=1,404)
Sí
Tasa de eventos absoluta: 3.7% vs 1%
valor p: p=<0.001
BACKGROUND: In patients with acute coronary syndromes, it is desirable to identify a sensitive serum marker that is closely related to the degree of myocardial damage, provides prognostic information, and can be measured rapidly. We studied the prognostic value of cardiac troponin I levels in patients with unstable angina or non-Q-wave myocardial infarction. METHODS: In a multicenter study, blood specimens from 1404 symptomatic patients were analyzed for cardiac troponin I, a serum marker not detected in the blood of healthy persons. The relation between mortality at 42 days and the level of cardiac troponin I in the specimen obtained on enrollment was determined both before and after adjustment for baseline characteristics. RESULTS: The mortality rate at 42 days was significantly higher in the 573 patients with cardiac troponin I levels of at least 0.4 ng per milliliter (21 deaths, or 3.7 percent) than in the 831 patients with cardiac troponin I levels below 0.4 ng per milliliter (8 deaths, or 1.0 percent; P or = 65 years). CONCLUSIONS: In patients with acute coronary syndromes, cardiac troponin I levels provide useful prognostic information and permit the early identification of patients with an increased risk of death.
Antman et al. (Thu,) conducted a cohort in Acute coronary syndromes (unstable angina or non-Q-wave myocardial infarction) (n=1,404). Cardiac troponin I levels ≥0.4 ng/mL vs. Cardiac troponin I levels <0.4 ng/mL was evaluated on Mortality at 42 days (p=<0.001). Cardiac troponin I levels ≥0.4 ng/mL were associated with significantly higher 42-day mortality compared to levels <0.4 ng/mL (3.7% vs 1.0%, P<0.001) in patients with acute coronary syndromes.